| Name | ENLOPLATIN |
| Synonyms | CL-287110 ENLOPLATIN (SP-4-2)-[1,1-Cyclobumnedicarboxylato(2-)](tetrahydro-4H-pyran-4,4-dimethanamine-N,N')platinum platinum, (1,1-cyclobutanedicarboxylato(2-))(tetrahydro-4h-pyran-4,4-dimethanam (sp-4-2)-ine-n cis-(1,1-cyclobutanedicarboxylato)(tetrahydro-4h-pyran-4,4-bis(methylami ne)) platinum cl 287110 enloplatin |
| CAS | 111523-41-2 |
| Molecular Formula | C13H22N2O5Pt |
| Molar Mass | 481.4 |
| Melting Point | 260-263 °C (decomp) |
| Physical and Chemical Properties | Chemical Properties Acute Toxicity LD50 Rats (mg/kg):200 Intravenous Injection. |
| Use | Third generation platinum complexes used in the development of anti-tumor drugs. Its antitumor activity spectrum is wider than that of cisplatin, and the renal toxicity is lower. |
| Raw Materials | Potassium carbonate Malononitrile Ammonium phosphate dibasic 1,1-Cyclobutanedicarboxylic acid Cyclopropane Tetrahydropyran dipotassium tetrachloroplatinate Platinum dichloride |
2,2 '-dichloroethyl ether and malononitrile, using potassium carbonate as the condensing agent, refluxing in acetonitrile solvent to obtain 4, 4-dicyanotetrahydropyran, and then the cyano group Reduced to an amino group, reacted with potassium chloroplatinate, and then condensed with silver cyclobutane -1, 1-dicarboxylate to obtain a product. You can also first react potassium chloroplatinate and dimethyl sulfoxide to obtain bis-dimethyl sulfoxide platinum dichloride, and then react with silver cyclobutane -1, 1-dicarboxylate to obtain (1,1-Cyclobutane-dicarboxylic acid-O,O') bis-dimethyl sulfoxide platinum.
The obtained platinum complex is condensed with 4, 4-diamine methyltetrahydropyran to obtain a product.